When research scientists and engineers come together with NGOs and key stakeholders from the private and public sectors, they can help solve the world’s toughest problems. Drawing from projects conducted at IBM Research including many under its Science for Social Good program, Aleksandra “Saska” Mojsilovic illustrates the historic opportunities for AI and deep science to address the world’s biggest social impact challenges. This includes IBM’s recent efforts using advanced technology to tackle COVID-19 and help the research and medical communities understand the virus and expedite discovery of a treatment.